Frame announces research collaboration with eTheRNA immunotherapies NV

Frame announces research collaboration with eTheRNA immunotherapies NV

Amsterdam (The Netherlands) and Niel (Belgium)
Frame Therapeutics happily announces a new research collaboration with eTheRNA immunotherapies NV (eTheRNA) to develop mRNA cancer vaccines against immunogenic neoantigens.

eTheRNA is a Belgian clinical-stage company developing vaccines and immunotherapies from its proprietary mRNA TriMix platform. The collaboration aims to develop a new generation of off-the-shelf neoantigen cancer vaccines by combining each company’s immunotherapy expertise and unique technologies. Frame Therapeutics will contribute the discovery and development of the highly immunogenic frameshift neoantigens that are only expressed in specific tumor types and thus offer a new level of patient and tumor specificity. eTheRNA will apply its vaccination technology platform to elicit anti-tumor T-cell responses based by employing its clinically validated TriMix mRNA platform.
 
Ronald Plasterk, CEO of Frame Therapeutics commented: “Our business is focused on discovery of new antigens for cancer vaccination. Our neoantigens form a good match with eTheRNA’s TriMix technology. By combining the best content with the best vaccine platform we are confident to make a major step forward in cancer therapeutic vaccines”.
 
Steven Powell, CEO of eTheRNA immunotherapies commented: “Frame Therapeutics’ work with neoantigens is impressive and we see a natural fit with our TriMix platform. We look forward to studying the clinical potential of delivering neoantigens to tumors and opening a new chapter in cancer immunotherapy”.

Frame Therapeutics                                                       
info@frametherapeutics.com                                     +31 20 237 49 70

eTheRNA 
media@etherna.be                                                        +44 7711 821527
Richard Hayhurst                                                           richard@rhapr.eu 

About Frame Therapeutics
Frame Therapeutics is a privately funded startup company in the Amsterdam Science Park founded in December 2018. Frame Therapeutics’ goal is to develop its proprietary approach for immunotherapy against cancer, which is based on precise analysis of the DNA and RNA of the tumor of a patient, and using that information to supply the best vaccine against properties specific for the tumor. The strong anti-tumor immune response elicited by Frame vaccines may contribute to major clinical benefits for patients with cancer.
 
About eTheRNA immunotherapies NV
eTheRNA immunotherapies NV is a clinical-stage company delivering innovative cancer immunotherapies from its proprietary mRNA-based TriMix platform. eTheRNA’s goal is to commercialize these immunotherapies to deliver long lasting clinical remission to cancer patients. eTheRNA was established in January 2013 as a spin-off from the VUB university in Belgium. 
 
About TriMix
The TriMix platform, on which eTheRNA’s immunotherapies are based, comprises three mRNAs encoding proteins (caTLR4, CD40L and CD70) that work to deliver optimal activation of dendritic cells. These cells behave as immune response mediators and mobilize the immune system to attack cancer cells through inducing a T-cell response. Clinical proof of concept for TriMix-based immunotherapies has been established through an extensive dataset demonstrating clear clinical benefits in advanced melanoma patients.
 
About the Frame Technology
Frame Therapeutics’ neoantigen technology is based on the identification of a large number of shared neoantigens, which result from frameshift mutations in tumors. Although the majority of frameshift mutations occur at different positions in a gene, the resulting novel protein products are common to large numbers of tumors from different patients. Combined with the long stretches of novel amino acid sequences encoded by frameshifts, these neoantigens represent attractive and highly immunogenic targets for cancer immunotherapy.

Amsterdam (The Netherlands) and Niel (Belgium)
Frame Therapeutics happily announces a new research collaboration with eTheRNA immunotherapies NV (eTheRNA) to develop mRNA cancer vaccines against immunogenic neoantigens.

eTheRNA is a Belgian clinical-stage company developing vaccines and immunotherapies from its proprietary mRNA TriMix platform. The collaboration aims to develop a new generation of off-the-shelf neoantigen cancer vaccines by combining each company’s immunotherapy expertise and unique technologies. Frame Therapeutics will contribute the discovery and development of the highly immunogenic frameshift neoantigens that are only expressed in specific tumor types and thus offer a new level of patient and tumor specificity. eTheRNA will apply its vaccination technology platform to elicit anti-tumor T-cell responses based by employing its clinically validated TriMix mRNA platform.
 
Ronald Plasterk, CEO of Frame Therapeutics commented: “Our business is focused on discovery of new antigens for cancer vaccination. Our neoantigens form a good match with eTheRNA’s TriMix technology. By combining the best content with the best vaccine platform we are confident to make a major step forward in cancer therapeutic vaccines”.
 
Steven Powell, CEO of eTheRNA immunotherapies commented: “Frame Therapeutics’ work with neoantigens is impressive and we see a natural fit with our TriMix platform. We look forward to studying the clinical potential of delivering neoantigens to tumors and opening a new chapter in cancer immunotherapy”.

Frame Therapeutics                                                       
info@frametherapeutics.com                                     +31 20 237 49 70

eTheRNA 
media@etherna.be                                                        +44 7711 821527
Richard Hayhurst                                                           richard@rhapr.eu 

About Frame Therapeutics
Frame Therapeutics is a privately funded startup company in the Amsterdam Science Park founded in December 2018. Frame Therapeutics’ goal is to develop its proprietary approach for immunotherapy against cancer, which is based on precise analysis of the DNA and RNA of the tumor of a patient, and using that information to supply the best vaccine against properties specific for the tumor. The strong anti-tumor immune response elicited by Frame vaccines may contribute to major clinical benefits for patients with cancer.
 
About eTheRNA immunotherapies NV
eTheRNA immunotherapies NV is a clinical-stage company delivering innovative cancer immunotherapies from its proprietary mRNA-based TriMix platform. eTheRNA’s goal is to commercialize these immunotherapies to deliver long lasting clinical remission to cancer patients. eTheRNA was established in January 2013 as a spin-off from the VUB university in Belgium. 
 
About TriMix
The TriMix platform, on which eTheRNA’s immunotherapies are based, comprises three mRNAs encoding proteins (caTLR4, CD40L and CD70) that work to deliver optimal activation of dendritic cells. These cells behave as immune response mediators and mobilize the immune system to attack cancer cells through inducing a T-cell response. Clinical proof of concept for TriMix-based immunotherapies has been established through an extensive dataset demonstrating clear clinical benefits in advanced melanoma patients.
 
About the Frame Technology
Frame Therapeutics’ neoantigen technology is based on the identification of a large number of shared neoantigens, which result from frameshift mutations in tumors. Although the majority of frameshift mutations occur at different positions in a gene, the resulting novel protein products are common to large numbers of tumors from different patients. Combined with the long stretches of novel amino acid sequences encoded by frameshifts, these neoantigens represent attractive and highly immunogenic targets for cancer immunotherapy.